 |
|
Tau IHC Antibody
Ready To Use
| Catalog Number | Size | Price | Availability |
| IW-MA1093 | 9 ml | $258 | 1-2 weeks |
Description |
The microtubule-associated proteins (MAPs) coassemble with tubulin into microtubules in vitro. Microtubule-associated protein tau appears to be enriched in axons. Tau is composed of 352 to 441 amino acids. The isoforms differ from each other by the presence or absence of 29-amino acid or 58-amino acid inserts located in the N terminus and a 31-amino repeat located in the C terminus. Tau is important in establishing and maintaining neuronal morphology and is a major component of the neurofibrillary tangles (NFTs) characteristic of Alzheimer's brain. Microtubule-associated protein tau (MTBT1) is mapped to chromosome 17q21.
|
Catalog Number
|
IW-MA1093
|
Quantity
|
9 ml
|
|
Host |
Mouse
|
|
Clone |
TAU-93
|
|
Isotype |
Mouse IgG1
|
|
Immunogen |
Bovine microtubule-associated proteins (MAPs).
|
|
Purity |
Purified by the goat anti-mouse IgG affinity chromatography.
|
|
Conjugate |
Unconjuated
|
|
Species Reactivity |
Human, mouse, rat. Not tested in other species.
|
|
Positive Control |
Alzheimer’s brain tissue (neurofibrillary tangles, senile plaques).
|
|
Cellular Localization |
Cytoplasmic
|
|
Form |
Ready to use solution. No further dilution needed. Serum blocking step should be omitted.
|
|
Storage |
Store at 2-8 °C. Do not freeze.
|
|
Applications |
IHC-P: Heat induced epitope retrieval is
required on formalin fixed paraffin embedded sections. IHC-Fr: Not tested. ICC: Not tested.
|
|
Limitations |
This product is intended for Research Use Only. Interpretation of the test results is solely the responsibility of the user.
|
|
Precautions |
Users should follow general laboratory precautions when handling this product. Wear personal protective equipment to avoid contact with skin and eyes.
|
|
References |
1. Andreadis, A.;
Brown, W. M.; Kosik, K. S. :
Structure and novel
exons of the human tau gene.
Biochemistry
31: 10626-10633, 1992. 2. Donlon, T. A.; Harris, P.; Neve, R. L. : Localization of microtubule-associated protein tau (MTBT1) to chromosome 17q21. (Abstract) Cytogenet. Cell Genet. 46: 607, 1987.
|
|
Images |
|
Related Products