Catalog Number | Size | Price | Availability |
IW-PA1080 | 9 ml | $258 | Yes |
Description
|
VEGF, a homodimeric glycoprotein of relative molecular mass
45,000, is the only mitogen that specifically acts on
endothelial cells. It may be a major regulator of tumor
angiogenesis in vivo. Vascular endothelial growth factor is
a mitogen primarily for vascular endothelial cells. It is,
however, structurally related to platelet-derived growth
factor. VEGF shares homology with the PDGF A chain and B
chain, including conservation of all 8 cysteines found in
PDGFA and PDGFB. VEGF gene contains 8 exons.
Vascular
endothelial growth factor (VEGF) induces remodeling and
enhances TH2-mediated sensitization and inflammation in the
lung. VEGF
regulates haematopoietic stem cell survival by an internal
autocrine loop mechanism. Vascular endothelial growth factor
(VEGF) stimulates neurogenesis in vitro and in vivo. |
Catalog Number
|
IW-PA1080 |
Quantity
|
9 ml |
Host |
Rabbit |
Clone |
Polyclonal |
Isotype |
IgG |
Immunogen |
A synthetic peptide corresponding to a sequence near the N-teminal
end of VEGF of human origin, identical to the related rat
sequences. |
Purity |
Immunogen affinity purified |
Conjugate |
Unconjugated |
Species Reactivity |
Human, mouse, rat.
Not tested in other species. |
Positive Control |
Skin, Human esophagus squamous carcinoma. |
Cellular Localization |
Cytoplasmic |
Form |
Ready to use solution. No further dilution needed. Serum blocking step should be omitted. |
Storage |
Store at 2-8
°C.
Do not freeze. |
Applications |
IHC-P: Heat induced epitope retrieval is required on
formalin fixed paraffin sections.
IHC-Fr: Not tested.
ICC: Not tested. |
Limitations |
This product is intended for Research Use Only.
Interpretation of the test results is solely the
responsibility of the user. |
Precautions |
Users should follow general laboratory precautions when
handling this product. Wear personal protective equipment to
avoid contact with skin and eyes. |
References |
1. Lee, C. G.; Link, H.; Baluk,
P.; Homer, R. J.; Chapoval, S.; Bhandari, V.; Kang, M. J.;
Cohn, L.; Kim, Y. K.; McDonald, D. M.; Elias, J. A. :
Vascular
endothelial growth factor (VEGF) induces remodeling and
enhances TH2-mediated sensitization and inflammation in the
lung.
Nature Med. 10: 1095-1103, 2004.
2. Gerber, H.-P.; Malik, A. K.;
Solar, G. P.; Sherman, D.; Liang, X. H.; Meng, G.; Hong, K.;
Marsters, J. C.; Ferrara, N. :
VEGF regulates
haematopoietic stem cell survival by an internal autocrine
loop mechanism.
Nature 417:
954-958, 2002.
3. Jin, K.; Zhu, Y.; Sun, Y.;
Mao, X. O.; Xie, L.; Greenberg, D. A. :
Vascular
endothelial growth factor (VEGF) stimulates neurogenesis in
vitro and in vivo.
Proc. Nat. Acad.
Sci. 99: 11946-11950, 2002. |
Images |
Immunohistochemical analysis of formalin fixed paraffin-embedded
human esophagus squamous carcinoma using VEGF antibody.
Staining VEGF in cytoplasm. DAB chromogenic reaction |
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