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beta-Amyloid IHC Antibody
Ready To Use
| Catalog Number | Size | Price | Availability |
| IW-MA1109 | 9 ml | $258 | Yes |
Description |
beta-Amyloid protein is 4.2-kD polypeptide. Glenner and Wong (1984) purified a protein derived from the twisted beta-pleated sheet fibrils present in cerebrovascular amyloidoses and in the amyloid plaques associated with Alzheimer disease. The proteins from both disorders have an identical 28-amino acid sequence. memory deficits in middle-aged Tg2576 mice are caused by the extracellular accumulation of a 56-kDa soluble amyloid-beta assembly. Amyloid beta protein (Abeta) deposition in the brain is a hallmark of Alzheimer's disease (AD).
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Catalog Number
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IW-MA1109
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Quantity
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9 ml
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Host |
Mouse
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Clone |
AP-5
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Isotype |
Mouse IgG1
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Immunogen |
Synthetic β-amyloid peptide (1-40), conjugated to KLH.
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Purity |
Purified by the goat anti-mouse IgG affinity chromatography
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Conjugate |
Unconjugated
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Species Reactivity |
Human, mouse. Not tested in other species.
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Positive Control |
Alzheimer’s brain tissue.
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Cellular Localization |
Extracellular senile plaque and neurofibrillary tangles.
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Form |
Ready to use solution in PBS based antibody dilution buffer containing 0.01% sodium azide. No further dilution needed. Serum blocking step should be omitted.
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Storage |
Store at 2-8 °C. Do not freeze.
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Applications |
IHC-P: Formic acid pretreatment or heat
induced epitope retrieval (HIER) is
required on formalin fixed paraffin embedded tissue
sections. IHC-Fr: Not tested. ICC: Not tested.
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Limitations |
This product is intended for Research Use Only. Interpretation of the test results is solely the responsibility of the user.
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Precautions |
Users should follow general laboratory precautions when handling this product. Wear personal protective equipment to avoid contact with skin and eyes.
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References |
1. Lesne, S.;
Koh, M. T.; Kotilinek, L.; Kayed, R.; Glabe, C. G.; Yang,
A.; Gallagher, M.; Ashe, K. H. :
A specific amyloid-beta
protein assembly in the brain impairs memory.
Nature 440:
352-357, 2006. 2. Lorenzo, A.; Yuan, M.; Zhang, Z.; Paganetti, P. A.; Sturchler-Pierrat, C.; Staufenbiel, M.; Mautino, J.; Vigo, F. S.; Sommer, B.; Yankner, B. A. : Amyloid beta interacts with the amyloid precursor protein: a potential toxic mechanism in Alzheimer's disease. Nature Neurosci. 3: 460-464, 2000.
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