ABC of Safety in the Biological Sciences
ACRIFLAVINE (Colour Index No. 46000 (C14C15N3Cl2)
SYNONYMS
Trypaflavine, flavine, neutral trypaflavine, euflavin.
CHARACTERISTICS
Orangered or red crystalline powder. It is a mixture of
2,8diamino10 methylacridine chloride hydrochloride and
2,9diaminoacridine dihydrochloride. This dye is in the acridine
group of dyes.
INCOMPATIBILITY
Heating produces highly toxic fumes of nitrogen compounds.
HEALTH HAZARD DATA
This substance is moderately toxic and is an eye and respiratory
tract irritant. Hypersensitivity reactions can occur especially
after prolonged skin contact. Acriflavine stains skin yellow.
HANDLING and GENERAL PRECAUTIONS
Avoid skin and eye contact.
Avoid inhalation or ingestion of the powder.
Keep away from heat.
Wash hands thoroughly after handling.
Wear protective clothing to avoid skin or eye contact,
inhalation or ingestion. A long sleeved laboratory coat or gown,
rubber gloves, safety goggles and a face mask as a minimum
standard.
TREATMENTS
Skin immediately wash the affected area with soap or mild
detergent and large amounts of water until all evidence of the
chemical has been removed (approximately 15 minutes). If
hypersensitivity develops seek medical attention. Contaminated
clothing should be removed, dried and washed with strong soap
solution or destroyed. It may be necessary to destroy shoes by
burning.
Eyes wash the affected eye with large amounts of water until
all evidence of the chemical has been removed (approximately 15
minutes). If irritation or pain persist seek immediate medical
attention.
Inhalation remove from the area of exposure to fresh air. Keep
warm and allow to rest. If irritation persists or signs of
toxicity develop seek medical attention.
Ingestion wash out the mouth thoroughly with water and give
water to drink. Seek immediately medical advice.
STORAGE
Store in a cool, dry atmosphere away from heat.
DISPOSAL
Wear butyl rubber gloves, laboratory coat and self contained
breathing apparatus.
Spills: Small spills - absorb liquid on paper towels. Brush
solids on to paper. Place in an iron pan and allow evaporation
in a fume hood. Add crumpled paper and burn. Wash spill site
with a strong soap solution.
Large spills - cover with sand and soda ash mixture (90/10). Mix
and shovel into a cardboard box. Pack with a large excess of
crumpled paper. Burn in an open pit or incinerator equipped with
an afterburner and scrubber.
Package lots: Either - 1. Pour or sift on to a thick layer of
sand and soda ash mixture (90/10). Mix, and shovel into a heavy
paper box with much paper packaging. Burn in an incinerator. The
fire may be augmented with scrap wood. Stay on the upwind side
OR 2. Dissolve in a flammable solvent and spray into the firebox
of an incinerator equipped with an afterburner and scrubber.
ENVIRONMENT:
No data available.
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