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Histopathology Artifacts Quiz
This slide shows areas which crystals once occupied but which dissolved during fixation and processing. The characteristic shape suggests cholesterol which is often deposited as tapering needle-crystals in vessel walls in atheroma and in various sites of old haemorrhage. A more common example of the loss of soluble substances is seen when neutral fat is dissolved from fat cells leaving regular ovoid spaces surrounded by a rim of cytoplasm. So the correct answer is loss of soluble substance.
© Roy C. Ellis 2004