Histopathology Artifacts Quiz



This slide shows ice-crystal artefact which appears as intercellular clefts in highly cellular tissues and as intracellular clefts and vacuoles in skeletal muscle. This common problem results from the slow freezing of tissue through inappropriate quenching techniques or the selection of tissue samples too large to permit rapid freezing throughout the specimen. Consequently ice-crystal artefact is most prominent in the central region of the specimen. Answer ice crystal artefact.

© Roy C. Ellis 2004