Histopathology Artifacts Quiz



When fresh some tissues, such as lymph node, are very susceptible to damage from crushing with forceps or other surgical instruments. This Micrograph shows this crush artefact or compression quite well. At one margin the section shows darkly staining, distorted cell nuclei, some obviously stretched out and flattened, but maintaining an intense basophilia. Some are almost fibre-like. Normal tissue is present below this area. This artefact is typically seen at the periphery of specimens and is usually in small, localised areas. Answer crush or compression artefact.

© Roy C. Ellis 2004