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Problems in Histopathological Technique
Prepared by
ROY ELLIS
IMVS Division of Pathology
The Queen Elizabeth Hospital
Woodville Road, Woodville, South Australia 5011
Email: roy.ellis@imvs.sa.gov.au
Did you know that nucleoli stain blue after Zenker
fixation?
Nucleoli are composed mainly of RNA and usually stain red after
eosin staining in a Haematoxylin and Eosin. So it is unusual that
after Zenker fixation they stain blue. Try it out on a piece of
tissue from a tumour, where cells are very active and you should
find many blue nucleoli but they can sometimes be difficult to
detect in a nucleus that also stains the same colour.Click the button to return to the Home Page
© Roy C. Ellis 2002